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Vietnam: H5N1 variation (clade 2.3.4) vaccines powerless

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Friday, 02/17/2012 22:32

The avian influenza virus was genetically engineered into the new virus is highly virulent, contagious and resistant to vaccines. While Vietnam does not have A/H5N1 flu vaccine on humans

While bird flu continues to spread to many provinces, the deadly virus have been many changes detrimental to the prevention and treatment measures in poultry. More worrying when the death rate from influenza A/H5N1 in humans is 100% of cases are detected.

Resistant virus vaccine

On 17-2, Hoang Van Nam, Director of Animal Health authority (Ministry of Agriculture - Rural Development), said from the beginning of this year has 11 local detection of avian influenza including Thanh Hoa, Quang Tri, Soc Trang, Ha Nam, Hai Duong, Thai Nguyen, Kien Giang, Bac Giang, Ha Tinh and Hai Phong and Quang Nam.

Not yet quarantined poultry still be comfortable buying and selling, slaughtering in Hanoi

There were nearly 20,000 birds, mostly ducks to be destroyed. The bird flu is complicated, spread in all 3 regions. If loose slaughtering operations management, transportation and trade of poultry, the risk of widespread outbreaks is huge.

Risk of spreading bird flu, today (18-2) National Steering Committee for prevention of avian influenza will have an emergency meeting to discuss measures to cope. Meanwhile, Mr. Diep Kinh Tan on 17-2, Deputy Minister of Agriculture - Rural Development, said it had written to the Prime Minister requests the State budget of 13 billion contract to buy 50 million doses of H5N1 vaccine Re-vaccination strains fifth round of 1-2012 for timely enclosure, stamping out.

According to Tan, 2012 is expected to need 327 million doses of vaccine given to poultry, but due to bird flu virus in the northern provinces with the change, the vaccine strain H5N1 Re-5 protection levels households is not high. Meanwhile, in the southern provinces, not bird flu virus is modified to use H5N1 vaccines imported from China, so immediate permission to import 50 million doses.

The risk to humans is very large

According to experts, the bird flu virus may be genetically caused the surveillance becomes more difficult. Department of Animal Health representative said before, there are 3 branches Vietnam H5N1 virus has been detected. A branch in the south, north branch and the branch 2.3.4 7 capable of highly infectious.

However, recently in the northern provinces, discovered a new bird flu virus branch, symbol 2.3.2 branch. More worryingly, had discovered the virus 2.3.2 branch into 2 groups. With a group of old virus, vaccine against bird flu meets only 75%, while the new virus, vaccines are currently using does not work. Therefore, the risk of spreading the virus in poultry and humans is very large. What is more dangerous than professional bodies continue on raising waterfowl flocks, sold in many places but no signs or symptoms but still carry the virus H5N1.

Dr. Nguyen Hong Ha, deputy director of Tropical Diseases Hospital Central, concerned with the weather hot and humid climate are favorable for growing influenza virus. Moreover, with the normal seasonal flu viruses such as influenza B, H1N1, H3N1, H5N1 ... the risk is present, the virus strains combine or mutate to create new influenza virus virulent more dangerous is huge. Currently, flu vaccines are being used in Vietnam is just common flu as influenza A (H3N1, H3N2, H1N1) and there is no vaccine against A/H5N1 flu in humans.
100% mortality rate

According to Dr. Tran Thanh Duong, deputy director of the Department of Preventive Health (MOH), A/H5N1 flu spread from birds, waterfowl infected with influenza A/H5N1 virus to humans is strongly virulent virus, the mortality rate very high. At this point, the rate of death from influenza A/H5N1 in humans is 100% of cases were detected. Two cases were patients who died despite antiviral treatment.

http://nld.com.vn/20120217102740382p0c1002/virus-h5n1-bien-doi-vacxin-bat-luc.htm

 

Full phylogenetic tree of H5N1 sequences
http://www.who.int/influenza/gisrs_labo ... lltree.pdf

swine flu h5n1 mutation virus evolution flu bird flu avian flu vaccine Vietnam clade 2.3.4

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